Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
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Auteurs : Karlynn E. Neu [États-Unis] ; Carole J. Henry Dunand [États-Unis] ; Patrick C. Wilson [États-Unis]Source :
- Current opinion in immunology [ 0952-7915 ] ; 2016.
Abstract
Current seasonal influenza virus vaccines are effective against infection but they have to be reformulated on a regular basis to counter antigenic variations. The majority of the antibodies induced in response to seasonal vaccination are strain-specific. However, antibodies targeting conserved epitopes on the hemagglutinin protein have been identified and they offer broad protection. Most of these antibodies bind the hemagglutinin stalk domain and are generated from preexisting memory B cells. Broadly protective stalk-biased responses induced by antigenically divergent influenza strains, in concert with prior immunity, are sufficient to eradicate seasonally circulating strains. Future vaccine trials should aim to harness and maintain such a response with the realistic goal of developing a universal influenza vaccine.
Url:
DOI: 10.1016/j.coi.2016.05.012
PubMed: 27268395
PubMed Central: 5086271
Affiliations:
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Neu</name><affiliation wicri:level="4"><nlm:aff id="A1">Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Committee on Immunology, The University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Henry Dunand, Carole J" sort="Henry Dunand, Carole J" uniqKey="Henry Dunand C" first="Carole J." last="Henry Dunand">Carole J. Henry Dunand</name><affiliation wicri:level="4"><nlm:aff id="A2">The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois 60637</wicri:regionArea><orgName type="university">Université de Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><affiliation wicri:level="4"><nlm:aff id="A1">Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Committee on Immunology, The University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois 60637</wicri:regionArea><orgName type="university">Université de Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">Current opinion in immunology</title><idno type="ISSN">0952-7915</idno><idno type="eISSN">1879-0372</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Current seasonal influenza virus vaccines are effective against infection but they have to be reformulated on a regular basis to counter antigenic variations. The majority of the antibodies induced in response to seasonal vaccination are strain-specific. However, antibodies targeting conserved epitopes on the hemagglutinin protein have been identified and they offer broad protection. Most of these antibodies bind the hemagglutinin stalk domain and are generated from preexisting memory B cells. Broadly protective stalk-biased responses induced by antigenically divergent influenza strains, in concert with prior immunity, are sufficient to eradicate seasonally circulating strains. Future vaccine trials should aim to harness and maintain such a response with the realistic goal of developing a universal influenza vaccine.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Neu, Karlynn E" sort="Neu, Karlynn E" uniqKey="Neu K" first="Karlynn E." last="Neu">Karlynn E. Neu</name></region><name sortKey="Henry Dunand, Carole J" sort="Henry Dunand, Carole J" uniqKey="Henry Dunand C" first="Carole J." last="Henry Dunand">Carole J. Henry Dunand</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. 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